Review Note
Last Update: 03/30/2025 10:07 PM
Current Deck: ACG Part 2::Plastic Surgery and Burns
New Card (Unpublished)Currently Published Content
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Front
Commit #312092
SS_PB 1.1 Describe the physiological principles relevant to optimising blood flow to tissue flaps, including:
- Oxygen transport and delivery.
- Oxygen transport and delivery.
Back
Commit #312092Oxygen Transport in Blood
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Oxygen is carried in the blood as a dissolved fraction and bound to hemoglobin (97%).
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Oxygen transport is determined by the oxygen flux equation:
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DO₂ = CO × [Hb] × SpO₂ × Hüfner’s constant (1.39) + 0.023 × PaO₂
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Oxygen Dissociation Curve
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The binding of O₂ to hemoglobin is a cooperative process, making the curve sigmoidal.
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Several factors influence Hb-O₂ binding:
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Right shift (favoring O₂ unloading in metabolically active tissues):
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↓ pH (Bohr effect)
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↑ Temperature
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↑ 2,3-DPG
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↑ CO₂
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Left shift (favoring O₂ binding):
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↑ pH
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↓ CO₂
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↓ Temperature
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↓ 2,3-DPG
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