Notes in 01_Understanding Haemolytic Anaemia

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Published	02/10/2024	Presentation of {{c2::Haemolytic Anaemia}}  {{c1::Jaundice}} {{c1::Hepatosplenomegaly}} {{c1::Dark urine (Intravascular Haemosiderinuria)}} …
Published	02/10/2024	Congenital Causes of Haemolytic Anaemia[1] {{c1::Hereditary spherocytosis (HS)}}[2] {{c1::G6PD deficiency}}[3] {{c1::Haemoglobinop…
Published	02/10/2024	Acquired Causes of Haemolytic Anaemia[1] {{c1::Autoimmune haemolytic anaemia (e.g. Chronic Lymphocytic Leukaemia, Lymphoma)}}[2] {{c1::…
Published	02/10/2024	Pathophysiology of Haemolytic Anaemia {{c1::Increased destruction of red blood cells and a reduction of their circulating lifespan which is why there …
Published	02/10/2024	{{c1::Extravascular/Immunr}} Haemolysis occurs within the {{c2::reticuloendothelial system}} where RBCs are removed from the circulation as they are d…
Published	02/10/2024	{{c1::Intravascular/Non-Immune}} Haemolysis occurs within the {{c2::blood vessels}} where RBCs are removed due to trauma, complement fi…
Published	02/10/2024	Congenital Anaemias include {{c1::Hereditary Spherocytosis}} and {{c1::G6PD Deficiency}}
Published	02/10/2024	Approach to Haemolytic AnaemiaAsk yourself two questions:One: {{c1::Is the patient haemolysing?}}Two: {{c1::What is the mechanism of haemolysis (Intra…
Published	02/10/2024	Investigations to Determine if a patient is Haemolysing {{c1::Full Blood Count (Anaemic picture)}} {{c1::High reticulocyte count}} {{c1::Blood film (S…
Published	02/10/2024	Approach to Determining Mechanism of Haemolysis (Intravascular/Extravascular)[1] {{c1::History and Examination}}[2] {{c1::Direct Antiglobulin Tes…
Published	02/10/2024	Patients with {{c2::Extravascular}} Haemolysis present with {{c1::Jaundice}} and {{c1::Splenic Hypertrophy}}
Published	02/10/2024	Patients with {{c2::Intravascular}} Haemolysis present with {{c1::Jaundice}} and {{c1::Dark Urine (Haemosiderinuria)}}
Published	02/10/2024	a {{c1::Positive (DAT +ve)}} Direct Antiglobulin Test indicates {{c2::Extravascular}} Haemolysis
Published	02/10/2024	a {{c1::Negative (DAT -ve)}} Direct Antiglobulin Test indicates {{c2::Intravascular}} Haemolysis
Published	02/10/2024	The presence of  {{c1::Haemoglobin}}, {{c1::Haemosiderin}} and {{c1::Urobilinogen}} in urine indicates {{c2::Intravascular}} Haemolysis
Published	02/10/2024	Investigations of {{c2::Intravascular/Non-Immune}} Haemolytic Anaemia {{c1::Decreased haptoglobin}} {{c1::Negative DAT (Implies an non-immune basis fo…
Published	02/10/2024	Investigations of {{c2::Extravascular/Immune}} Haemolytic Anaemia {{c1::Positive DAT (Implies an immune basis for haemolysis)}} {{c1::No presence of H…
Published	02/10/2024	Treatment of Extravascular Haemolytic Anaemia {{c1::Support marrow function (e.g. folic acid)}} {{c1::Immunosuppression (Steroids &…
Published	02/10/2024	Treatment of Intravascular Haemolytic Anaemia {{c1::Support marrow function (e.g. folic acid)}} {{c1::Splenectomy: remove site of red cell d…
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